Variations of elemental distribution in brain regions of neonatal rats at different iodine intakes |
| |
Authors: | Zhang Fang Liu Nianqing Zhao Xueqin Zuo Aijun Yang Lei Xu Qing Wang Xuefei Huang Yuying He Wei Chai Zhifang |
| |
Institution: | (1) Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Academia Sinica, 100039 Beijing, People’s Republic of China;(2) Sychrotron Radiation Laboratory, Institute of High Energy Physics, Academia Sinica, 100039 Beijing, People’s Republic of China;(3) Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, People’s Republic of China;(4) Anatomy Department, Beijing University Health Science Center, 100083 Beijing, People’s Republic of China |
| |
Abstract: | Iodine deficiency (ID) can result in irreversible damage to the brain during the fetal and neonatal stages. As the active
center of many enzymes, trace elements play essential roles in brain function. In this work, the relative contents and distributions
of elements (Cl, Br, Fe, Cu, and Zn) in two important brain regions, the cerebral cortex and hippocampus, of the iodine-deficient
model rats were determined by the synchrotron radiation X-ray fluorescence (SRXRF) method. Meanwhile, the ID rats were supplemented
with adequate and excessive iodine, respectively. The results indicated that the distributions of trace elements could be
influenced by the different iodine intakes in the stage of brain development. In contrast to the control group, the contents
of Cl, Br, and Zn in two brain regions showed a significant increase in the ID group; however, both Fe and Cu decreased in
the cerebral cortex and increased in the hippocmapus in the ID group. In addition, only slight changes of elemental contents
in brain were found between the adequate and excessive iodine-supplemented rats. |
| |
Keywords: | Iodine deficiency trace element SRXRF cerebral cortex hippocampus |
本文献已被 PubMed SpringerLink 等数据库收录! |
|