Lamellipodium extension and membrane ruffling require different SNARE-mediated trafficking pathways |
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| Authors: | Michael Skalski Qing Yi Michelle J Kean Dennis W Myers Karla C Williams Angela Burtnik Marc G Coppolino |
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| Affiliation: | (1) Department of Molecular and Cellular Biology, University of Guleph, Guelph, ON N1G 2W1, Canada |
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| Abstract: | Background Intracellular membrane traffic is an essential component of the membrane remodeling that supports lamellipodium extension during cell adhesion. The membrane trafficking pathways that contribute to cell adhesion have not been fully elucidated, but recent studies have implicated SNARE proteins. Here, the functions of several SNAREs (SNAP23, VAMP3, VAMP4 and syntaxin13) are characterized during the processes of cell spreading and membrane ruffling. |
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