Structural principles for periodic orbits in glass networks |
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Authors: | Linghong Lu Roderick Edwards |
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Institution: | 1. Department of Mathematics and Statistics, University of Victoria, PO Box 3060, STN CSC, Victoria, BC, V8W 3R4, Canada
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Abstract: | A piecewise-linear differential equation model framework for gene regulatory interactions (Glass networks) has allowed considerable
analysis of qualitative dynamics in such systems, including periodicity, an important class of regulatory behaviors. Here,
we present new results relating the structure of the network to its dynamics (structural principles). The structure we refer
to is the state space of the network, which is a digraph on an n-cube in the case of a single threshold per gene. In particular, we show that for a wide class of cycles in the state space
there exist parameter values, consistent with the graph structure, for which a periodic orbit exists in the network. For some
classes, we show in addition that stable periodic orbits exist. These results extend greatly earlier work by Glass and Pasternack (J Math Biol 6:207–223, 1978). |
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