| 双歧杆菌活菌胶囊预防CPT-11引起的化疗相关性腹泻的疗效观察 |
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| 引用本文： | 方立萍,吴紫权,宋晨,郑培实,陈骏.双歧杆菌活菌胶囊预防CPT-11引起的化疗相关性腹泻的疗效观察[J].中国微生态学杂志,2011,23(3):241-242. |
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| 作者姓名： | 方立萍 吴紫权 宋晨 郑培实 陈骏 |
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| 作者单位： | 1. 大连医科大学附属第二医院,肿瘤内科,辽宁,大连,116023
2. 大连沙医生整形美容口腔专科医院,辽宁,大连,116023 |
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| 摘 要： | 目的观察双歧杆菌活菌胶囊预防伊立替康(CPT-11)引起的化疗相关性腹泻的疗效。方法 36例患者随机分成2组,观察组:化疗+双歧杆菌活菌胶囊,对照组:单纯化疗。观察患者治疗前后的KPS评分和腹泻的发生率及分级。结果观察组化疗前后KPS评分无明显变化,对照组化疗后KPS评分明显下降,差异有统计学意义,观察组Ⅰ～Ⅱ级腹泻发生率为33.3%,对照组为50%,2组差异有统计学意义(P<0.01)。观察组Ⅲ～Ⅳ级腹泻发生率为5.5%,对照组为27.8%,2组差异有统计学意义(P<0.01)。结论应用双歧杆菌活菌胶囊预防化疗相关性腹泻有良好的效果。
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| 关 键 词： | 化疗 腹泻 双歧杆菌 CPT-11 |
A clinical trial on preventive efficacy on CPT-11-induced diarrhea by bifidobacterium capsules |
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| FANG Li-ping,WU Zi-quan,SONG-Chen,ZHENG Pei-shi,CHEN-Jun.A clinical trial on preventive efficacy on CPT-11-induced diarrhea by bifidobacterium capsules[J].Chinese Journal of Microecology,2011,23(3):241-242. |
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| Authors: | FANG Li-ping WU Zi-quan SONG-Chen ZHENG Pei-shi CHEN-Jun |
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| Institution: | FANG Li-ping1,WU Zi-quan2,SONG-Chen1,ZHENG Pei-shi1,CHEN-Jun1 (1.Department of Oncology of the Second Affiliated Hospital of Dalian Medical University,Dalian 116023,China,2.Doctor Sha Cosmetic Surgery & Dental Clinic,China) |
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| Abstract: | Objective To observe the preventive efficacy on CPT-11-induced diarrhea by bifidobacterium capsules. Method 36 patients were randomized into observation group treated with chemotherapy plus bifidobacterium capsules and control with chemotherapy alone.Karnofsky performance status(KPS),diarrhea incidence and its grade were recorded for each patient both at baseline and post treatment. Result Compared with the baseline,KPS post chemotherapy showed no statistical difference in the observation group,but a signif... |
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| Keywords: | Chemotherapy Diarrhea Bifidobacterium CPT-11 |
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