Costimulatory regulation of T cell function |
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| Authors: | Chambers C A Allison J P |
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| Institution: | Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA. chambers@socrates.berkeley.edu |
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| Abstract: | During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved. |
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