Coupled Na+ -K+ transport in vesicles containing a purified (NaK)-ATPase and only phosphatidyl choline. |
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Authors: | S Hilden L Hokin |
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Affiliation: | Department of Pharmacology University of Wisconsin, Medical School Madison, Wisconsin 53706 USA |
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Abstract: | Endogenous phospholipids of a purified (NaK)-ATPase were displaced by exogenous phosphatidyl choline. If vesicles were made from phosphatidyl choline and enzyme containing only phosphatidyl choline, coupled Na+K+ transport could be demonstrated. This transport was inhibitable by ouabain. Therefore, the number of components necessary for Na+K+ transport has been reduced to the purified (NaK)-ATPase and one phospholipid. |
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