Allelic variation adjacent to the human insulin and apolipoprotein C-II genes in different ethnic groups |
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Authors: | L. G. Williams N. I. Jowett M. A. Vella S. Humphries D. J. Galton |
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Affiliation: | (1) Department of Medicine, St. Bartholomew's Hospital, London, UK;(2) Department of Biochemistry, St. Mary's Hospital, London, UK |
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Abstract: | Summary We have used DNA probes for the human insulin gene and apolipoprotein C-II (apo C-II) gene to determine the extent of allelic variation in different ethnic groups. The distribution of an apo C-II DNA polymorphism revealed by the restriction endonuclease Taq I showed no significant variation amongst racial groups; in contrast, an insulin gene-related DNA polymorphism showed marked variability. In Japanese, Chinese, and Asian Indian groups there was an increased frequency of homozygosity for the class 1 allele compared to Caucasian groups (P<0.001, P<0.01, and P<0.05, respectively). In Caucasian, Japanese, Chinese, and Asian Indian groups no class 2 allele was observed; but in the Negroid populations (African and West Indian) the class 2 allele frequencies were 0.23 and 0.25 respectively. Possible reasons for this variation in allele distribution are considered in relation to disease associations. |
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