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Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice |
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| Authors: | Edwin Reyniers Dirk R Van Bockstaele Kristel De Boulle R Frank Kooy Cathy E Bakker Ben A Oostra Patrick J Willems |
| Institution: | (1) Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium;(2) Laboratory of Experimental Haematology, University Hospital of Antwerp, B-2650 Edegem, Belgium;(3) Department of Clinical Genetics, Erasmus University, 3015 GE Rotterdam, The Netherlands |
| Abstract: | A slight increase in mean corpuscular hemoglobin (MCH) has been reported in erythrocytes from human fragile X patients. As it is difficult to perform casecontrolled studies in patients with fragile X syndrome, we studied MCH in erythrocytes from transgenic mice with an Fmr1 knockout. None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH. |
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