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High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF‐κB p65 pathway
Authors:Shengjie Wang  Jie Li  Jiwei Tian  Zhenghong Yu  Kun Gao  Jia Shao  Ang Li  Shuai Xing  Yonghui Dong  Zhiyong Li  Yanzheng Gao  Liping Wang  Cory J. Xian
Affiliation:1. Department of Orthopedics, Henan Provincial People's Hospital, Zhengzhou, China;2. Department of Orthopedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou Clinical Medical College of Nanjing, University of Chinese Medicine, Xuzhou, China;3. Department of Orthopedics, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;4. School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD, Australia;5. Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia
Abstract:
Keywords:cyclic mechanical strain  intervertebral disc degeneration  NF‐κ  B pathway  nucleus pulposus cells
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