Protective effect of miR378* on doxorubicin‐induced cardiomyocyte injury via calumenin |
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| Authors: | Yu Wang Xiaoxue Cui Yilin Wang Yao Fu Xin Guo Jie Long Chengxi Wei Ming Zhao |
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| Affiliation: | 1. Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China;2. Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio‐Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China;3. Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China |
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| Abstract: | Doxorubicin (Dox) is a highly effective antitumor antibiotic, however myocardial toxicity severely limits its use clinically. The pathogenesis of doxorubicin‐induced cardiomyopathy is unclear. In Dox cardiomyopathy mice, there is a decline in cardiac function, a change in myocardial pathology and a reduction in miR378* expression. Expression changes in calumenin, an endoplasmic reticulum stress (ERS) chaperone protein and pathway factor, as well as apoptosis, were observed in cardiomyocytes after doxorubicin‐induced injury. However, miR378* increased calumenin expression, eased ERS, and reduced cardiomyocyte apoptosis, while, silencing miR378* reduced calumenin expression, aggravated ERS, and increased cardiomyocyte apoptosis. The above results indicate that miR378* alleviates ERS and inhibits the activation of the ERS‐mediated apoptosis signaling pathway in cardiomyocytes via regulating calumenin expression, thereby reducing cardiomyocyte apoptosis after doxorubicin‐induced injury. Increasing miR378* expression may be a new way to improve cardiac function and quality of life in patients with Dox cardiomyopathy. |
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| Keywords: | apoptosis calumenin doxorubicin ERS miR378* |
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