Chronic taurine supplementation ameliorates oxidative stress and Na+ K+ ATPase impairment in the retina of diabetic rats |
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| Authors: | Di Leo M A S Santini S A Cercone S Lepore D Gentiloni Silveri N Caputo S Greco A V Giardina B Franconi F Ghirlanda G |
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| Institution: | (1) Department of Emergency Medicine, Catholic University, Rome, Italy, IT;(2) Department of Ophthalmology, Catholic University, Rome, Italy, IT;(3) Department of Internal and Geriatric Medicine, Catholic University, Rome, Italy, IT;(4) Institute of Biological Chemistry, Catholic University, Rome, Italy, IT;(5) Institute of Chemistry and Clinical Chemistry, Catholic University, Rome, Italy, IT;(6) Department of Pharmacology, University of Sassari, Sassari, Italy, IT |
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| Abstract: | Summary. This study evaluates the effect of 4 months supplementation with 2% and 5% taurine (w/w) on the retina of diabetic rats.
In non-diabetic rats, taurine does not modify glycemia, body weight, retinal conjugated dienes (CD), lipid hydroperoxide (LP),
and Na+K+ATPase activity. In diabetic rat, at 2, 4, 8, 16 weeks following the onset of diabetes, retinal CD and LP are significantly
and progressively increased, while pump activity is gradually and significantly reduced. In taurine supplemented diabetic
rats, glycemia is not affected but lipid peroxidation is significantly decreased. Finally, taurine preserves ATPase activity
being 5% more effective than 2% taurine. We conclude that taurine supplementation ameliorates biochemical retinal abnormalities
caused by diabetes, thereby suggesting that taurine may have a role in the prevention of retinal changes in diabetes.
Received November 26, 2001 Accepted January 10, 2002 Published online October 3, 2002
Authors' address: Prof. Flavia Franconi, Department of Pharmacology, University of Sassari, Via Muroni 23a, I-07100 Sassari, Italy, Fax: 39-79228715,
E-mail: franconi@ssmain.uniss.it |
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| Keywords: | : Diabetes mellitus Lipid peroxidation Glycemia Streptozotocin Na+K+ATPase |
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