Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats. |
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| Authors: | U K Mazumder M Gupta L Manikandan S Bhattacharya P K Haldar S Roy |
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| Affiliation: | Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. shila76in@yahoo.co.in |
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| Abstract: | The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma). The methanol extract (250 and 500 mg/kg(-1) p.o.) exhibited significant activity (p < 0.001) against all phlogistic agents used in a dose dependant manner. In the chronic model (cotton pouch granuloma method) the methanol extract exhibited significant anti-inflammatory activity. All these effects were compared with standard drug phenylbutazone (100 mg/kg(-1) p.o.). |
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