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Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect |
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| Authors: | Chosson Elizabeth Santoro Francesca Rochais Christophe Santos Jana Sopkova-de Oliveira Legay Rémi Thoret Sylviane Cresteil Thierry Sinicropi Maria Stefania Besson Thierry Dallemagne Patrick |
| Institution: | Université de Caen Basse Normandie, Centre d'Etudes et de Recherche sur le Médicament de Normandie UPRES EA 4258 - FR CNRS 3038 INC3M, UFR des Sciences Pharmaceutiques, Bd Becquerel, 14032 Caen cedex, France. |
| Abstract: | The synthesis of 7-oxo and 7-hydroxy trifluoroallocolchicinoids was achieved through the intramolecular cyclization of o-phenyl-β-phenylalanines. The resulting compounds were evaluated for their cytotoxic activity against KB cells and their inhibitory effect towards the polymerization of tubulin. The results yielded some potent cytotoxic compounds with correlated partial antitubulin effect. |
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