Fetal cells in the maternal circulation during first trimester in pregnancies |
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Authors: | Jui-Der Liou Chia C Pao Jyu Jen Hor Shu-Min Kao |
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Institution: | (1) Department of Obstetrics and Gynecology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan, Republic of China;(2) Department of Biochemistry, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan, Republic of China;(3) Department of Biochemistry, Chang Gung Medical College, 259 Wen Hwa Road, KweiShan, TaoYuan, Taiwan 33332, Republic of China |
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Abstract: | To investigate the presence of fetal cells in the maternal circulation during early pregnancy, the polymerase chain reaction was used to test the presence of human Y chromosome-specific ZFY and SRY gene DNA sequences in maternal peripheral blood specimens from 19 women carrying male fetuses and 12 women carrying female fetuses. The presence of fetal cells was suggested as early as 6 weeks gestation in 1 of the 19 women bearing male fetuses. Fetal cells were present in the maternal circulation of 15 of the 19 women by 9 weeks gestation, and in only 1 of the 19 were fetal cells not detected until the 12th week after conception. These results suggest that identification of fetal cells in the maternal circulation is possible with a properly designed and executed polymerase chain reaction. However, there was considerable variation with respect to when these fetal cells first became detectable during pregnancy. These fetal cells are potentially a valuable source of material for biochemical and genetic studies of the fetuses. |
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