Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish |
| |
Authors: | Kubota Yoshiaki Oike Yuichi Satoh Shinya Tabata Yoko Niikura Yuichi Morisada Tohru Akao Masaki Urano Takashi Ito Yasuhiro Miyamoto Takeshi Watanabe Sumiko Suda Toshio |
| |
Affiliation: | The Sakaguchi Laboratory, Department of Cell Differentiation, School of Medicine, Keio University, Tokyo, Japan. |
| |
Abstract: | Angiopoietin-like proteins (Angptls) are known to possess biological activities not only in the vascular system, but in the other mammalian tissues; however, their expression patterns and function in embryogenesis have not been extensively characterized. Here, we identify three zebrafish genes (Zangptl1, Zangptl2 and Zangptl6) highly homologous to mammalian Angptl1/ARP1, Angptl2/ARP2 and Angptl6/AGF, and describe their adult and embryonic temporal and spatial expression patterns. Zangptl1 is expressed faintly in the somites, while Zangptl2 is first detected in the yolk sac extension, spinal cord and branchial arches and is later expressed in the liver primordium and pectoral fin buds. Zangptl6 is expressed in the notochord. In addition to its embryonic expression, Zangptl2 is induced in adult fish during fin regeneration. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|