Interleukin-1, tumor necrosis factor-alpha,and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration |
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| Authors: | Katherine M Riera Nicole E Rothfusz Rebecca E Wilusz JB Weinberg Farshid Guilak Amy L McNulty |
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| Institution: | (1) Department of Orthopaedic Surgery, Duke University Medical Center, DUMC Box 3093, Durham, NC 27710, USA;(2) Department of Biomedical Engineering, Duke University, DUMC Box 3093, Durham, NC 27710, USA;(3) Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA;(4) Department of Medicine, VA Medical Center, E1006 VA Medical Center, 508 Fulton Street, Durham, NC 27705, USA |
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| Abstract: | Introduction Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) are up-regulated in injured and osteoarthritic knee joints. IL-1
and TNF-α inhibit integrative meniscal repair; however, the mechanisms by which this inhibition occurs are not fully understood.
Transforming growth factor-β1 (TGF-β1) increases meniscal cell proliferation and accumulation, and enhances integrative meniscal
repair. An improved understanding of the mechanisms modulating meniscal cell proliferation and migration will help to improve
approaches for enhancing intrinsic or tissue-engineered repair of the meniscus. The goal of this study was to examine the
hypothesis that IL-1 and TNF-α suppress, while TGF-β1 enhances, cellular proliferation and migration in cell and tissue models
of meniscal repair. |
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