The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling,virtual screening,and molecular docking studies |
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| Authors: | Shin-Hua Lu Josephine W Wu Hsuan-Liang Liu Jian-Hua Zhao Kung-Tien Liu Chih-Kuang Chuang Hsin-Yi Lin Wei-Bor Tsai Yih Ho |
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| Institution: | (1) Graduate Institute of Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., 10608 Taipei, Taiwan;(2) Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., 10608 Taipei, Taiwan;(3) Chemical Analysis Division, Institute of Nuclear Energy Research, 1000, Wunhua Rd., 32546 Longtan Township, Taoyuan County, Taiwan;(4) Division of Genetics and Metabolism, Department of Medical Research, Mackay Memorial Hospital, 92, Sec. 2, Chung-Shan N. Rd., 10449 Taipei, Taiwan;(5) College of Medicine, Fu-Jen Catholic University, 510 Chung Cheng Rd., 24205 Hsinchuang, Taipei County, Taiwan;(6) Department of Chemical Engineering, National Taiwan University, 1 Sec. 4 Roosevelt Rd., 106 Taipei, Taiwan;(7) School of Pharmacy, Taipei Medical University, 250 Wu-Hsing St., 110 Taipei, Taiwan |
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| Abstract: | Background Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly
people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role
in the regulation of the cholinergic system, and hence, inhibition of AChE has emerged as one of the most promising strategies
for the treatment of AD. |
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