高原鼠兔肾上腺皮质功能的每日节律及急性低氧效应

机体对各种有害刺激如冷、热、毒、损伤、缺氧等均产生应激反应,表现出肾上腺皮质功能增强,皮质激素分泌增加,从而提高了机体对外界恶劣环境的适应能力与耐受能力。本文试图探讨高原上的土生动物--高原鼠兔(Ochotona curzoniae)对低氧应激反应的特点,以及高原鼠兔肾上腺皮质酮分泌的每日节律(Circadian rhythm);并与实验大鼠进行比较。

THE CHANGING OF CORTICOSTERONE LEVEL IN NATIVE OCHOTONA CURZONIAE

The paper reported a circadian rhythm of corticosterone level and effect of acute simulated altitude on corticosterone concentration in native Ochotona curzoniae, and compared those effects between O. curzoniae and rats.In corticosterone secretion of O. curzoniae there was a circadian rhythm changing within a narrow range.The secretory high tide of corticosterone appeared at about 8 o'clock A. M. : plasma corticosterone concetration was 2.0±0.25μg/100ml (X±SE),adrenal corticosterone content was 0.21±0.020μg/100mg. But the secretory low tide was at about 3 o'clock P. M.: corticosterone levels were respectively 1.60±0.24μg/100ml and 0.17±0.026μg/100mg. The circadian rhythm of corticosterone in 0. curzoniae showed marked different from that in rats. After being simulated altitude exposure for 24 hours, the adrenal function of rats presented a significant activation with the rise in altitude. The corticosterone level of plasma and adrenal gland in O. curzoniae at thealtitude of 5000m was the same as that in control O. curzoniae maintained at the altitude of 2,300m. As altitude rose to 8,000m, adrenal corticosterone level of O. curzoniae began to rise, but it was not significant statistically.