Letter: L-3-hydroxyacyl coenzyme A dehydrogenase: crystallographic properties of the pig heart enzyme |
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| Authors: | M Weininger B E Noyes R A Bradshaw L J Banaszak |
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| Institution: | Department of Biological Chemistry Division of Biology and Biomedical Sciences Washington University School of Medicine St Louis, Mo. 63110, U.S.A. |
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| Abstract: | Crystals of l-3-hydroxyacyl coenzyme A dehydrogenase from pig heart that are suitable for X-ray analysis have been prepared and characterized. The enzyme is a mitochondrial protein important in the beta oxidation of fatty acids. It is of special interest because it requires coenzyme A-related molecules for its catalytic activity. For one of the crystalline forms of the enzyme, the X-ray data tend to confirm chemical observations that the molecule is a dimer of identical subunits. |
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