The orientation of the ligands in iron(III)-bleomycin intercalated with DNA |
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| Authors: | Howard Shields McGlumphy Charles |
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| Institution: | Department of Physics, Wake Forest University, Winston-Salem, NC 27109 U.S.A. |
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| Abstract: | EPR data show that Fe(III)-bleomycin intercalates with DNA, or that the Fe(III) coordination sphere has a fixed geometrical configuration with respect to the DNA helical axis. An analysis of the data from oriented DNA fibers, drawn from a viscous gel, shows that the angle between the fiber axis and the normal to a plane containing the Fe(III) ion and ligands ranges between 15 and 30 degrees. The principal g values for the low-spin Fe(III)-bleomycin-DNA complex at pH 7.5 are 2.45, 2.18 and 1.87 |
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| Keywords: | Iron(III)-bleomycin Ligand orientation DNA-antibiotic interaction |
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