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A new permutation strategy of pathway-based approach for genome-wide association study |
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| Authors: | Yan-Fang Guo Jian Li Yuan Chen Li-Shu Zhang Hong-Wen Deng |
| Affiliation: | (1) School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, PR China;(2) Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China;(3) Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri - Kansas City, Kansas City, MO 64108, USA;(4) Center of Systematic Biomedical Research, Shanghai University of Science and Technology, Shanghai, 200093, PR China;(5) College of Life Sciences and Engineering, Beijing Jiao Tong University, Beijing, 100044, PR China |
| Abstract: | BackgroundRecently introduced pathway-based approach is promising and advantageous to improve the efficiency of analyzing genome-wide association scan (GWAS) data to identify disease variants by jointly considering variants of the genes that belong to the same biological pathway. However, the current available pathway-based approaches for analyzing GWAS have limited power and efficiency. |
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