Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1 |
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| Authors: | Shin Joo-Ho Yang Jae-Won Le Pecheur Marie London Jacqueline Hoeger Harald Lubec Gert |
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| Affiliation: | (1) Department of Pediatrics, University of Vienna, Vienna, Austria;(2) Biochemisty Department, Universite Paris 7 Denis - Diderot, Paris, France;(3) Institute for Animal Breeding, University of Vienna, Vienna, Austria |
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| Abstract: | Background Cu/Zn-superoxide dismutase 1 (SOD1), encoded on chromosome 21, is a key enzyme in the metabolism of reactive oxygen species (ROS) and pathogenetically relevant for several disease states including Down syndrome (DS; trisomy 21). Systematically studying protein expression in human brain and animal models of DS we decided to carry out "protein hunting" for hypothetical proteins, i.e. proteins that have been predicted based upon nucleic sequences only, in a transgenic mouse model overexpressing human SOD1. |
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