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Pregnane alkaloids from Pachysandra axillaris |
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| Authors: | Yun Sun Yu-Xin Yan Jian-Chao Chen Xian-Min Zhang Ming-Hua Qiu |
| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China b Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China c Yunnan University of Traditional Chinese Medicine, Kunming 650000, Yunnan, People's Republic of China |
| Abstract: | Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC50 values of 11.17, 4.17, and 10.76 μM, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC50 values as 24.94 μM. |
| Keywords: | Pregnane alkaloids Pachysandra axillaris Cytotoxic activity |
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