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New bufadienolides and C23 steroids from the venom of Bufo bufo gargarizans |
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| Authors: | Hai-Yan Tian Xiao-Qi Zhang Dong-Mei Zhang Ying Wang Jun-Shan Liu Wen-Cai Ye |
| Affiliation: | a Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, PR China b Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Huangpu West Avenue 601, Guangzhou 510632, PR China c Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China |
| Abstract: | Six new bufadienolides (1-6) and two new C23 steroids (7 and 8), together with three known compounds (9-11) were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated by spectroscopic analysis and single-crystal X-ray diffraction. In vitro cytotoxicities of all compounds were evaluated in A549 cancer cell line. Compounds 2, 3 and 10 showed significant cytotoxic activities. |
| Keywords: | Toad venom Bufo bufo gargarizans Bufadienolide Cytotoxicity |
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