Thyroliberin and its analog lacking hormonal properties stimulate respiratory center activity in the frog Rana temporaria

It has been shown that thyroliberin and its synthetic analogue PR-546 injected into the lymphatic sacs (4.10(-7)-4.10(-9) g/kg) or applied to the medulla oblongata in the bulbar frogs (4.10(-10)-4.10(-12) g/kg) significantly increase the rate of motor respiratory volleys in the hypoglossal nerve. In preparations with the irregular level of the activity of the respiratory center, these drugs enhanced stabilization of the initial level of the rhythm of motor respiratory discharges.