Sporotrichosis Treatment: Overview and Update |
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Authors: | Beatriz Bustamante Pablo E Campos |
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Institution: | 1. Hospital Nacional Cayetano Heredia, Av. Honorio Delgado s/n, San Martin de Porres, Lima-31, Peru 2. Institute of Tropical Medicine, “Alexander von Humboldt”- Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima-31, Peru 3. School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima-31, Peru 4. Investigaciones Médicas en Salud-INMENSA, Calle Jose de la Torre Ugarte 166, Lince, Lima-14, Peru
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Abstract: | Sporotrichosis, caused by several species from the genus Sporothrix, mainly affects men working in agricultural labor. It is reported mostly from endemic regions located in tropical and subtropical
areas. Sporotrichosis usually affects subcutaneous tissue with no symptoms or mild symptoms, but it causes disseminated and
even fatal disease if the patient is immunocompromised. Significant progress in the knowledge of etiologic agents of sporotrichosis
has been achieved recently, but evaluations of treatment using well-designed clinical trials have been neglected. This article
reviews the drugs currently used to treat subcutaneous disease, describing the differences in their efficacy, and reviews
recent findings about the proposed new Sporothrix species of clinical interest, as well as the role of melanin as a virulence factor in Sporothrix schenckii. |
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