The acquisition of resistance to ecdysteroids in cultured Drosophila cells |
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| Authors: | Bryn Stevens,John D. O&#x Connor |
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| Affiliation: | Department of Biology, University of California, Los Angeles, Los Angeles, California 90024 USA |
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| Abstract: | Drosophila melanogaster Kc cells become refractory toward ecdysteroids after 4 days of exposure to the molting hormone, 20-OH-ecdysone. Associated with the appearance of hormonal insensitivity is a loss of ecdysteroid receptors. Hormone-resistant cells maintain a low level of receptor that is indistinguishable from that of responsive, hormonally naive cells. After extended periods in culture, ecdysteroid receptor content in previously exposed cells returns to that of naive control cells. The reappearance of receptor is coincident with the resumption of hormonally induced growth inhibition. |
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| Keywords: | To whom all correspondence should be addressed. |
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