Transient mass transfer processes during the perfusion of a biological organ with a cryophylactic agent solution |
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Authors: | Boris Rubinsky Ernest G Cravalho |
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Institution: | 1. Department of Mechanical Engineering, University of California, Berkeley, California 94720, U.S.A.;1. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 U.S.A. |
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Abstract: | An analytical study was performed for the mass transfer processes which occurs during a typical CPA introduction protocol in a biological organ. In such a protocol the concentration of CPA in the perfusate changes linearly with time to a maximal value and is then kept at that value for an additional period of time. Numerical solutions to the Kedem-Katchalsky equations for mass transfer processes in an organ modeled by a large number of typical Krogh tissue units were found. The solutions indicate that several phenomena possibly harmful to the organ occur in the tissue as a function of H, the rate of increase in the CPA concentration. |
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Keywords: | To whom correspondence and reprint requests should be addressed |
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