Osmoregulation of the HtrA (DegP) protease of Escherichia coli: an Hha-H-NS complex represses HtrA expression at low osmolarity |
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Authors: | Forns Núria Juárez Antonio Madrid Cristina |
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Institution: | Departament de Microbiologia, Universitat de Barcelona, Avda. Diagonal, 645, 08028 Barcelona, Spain. |
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Abstract: | The HtrA protein of Escherichia coli is a heat-shock inducible periplasmic protease, essential for bacterial survival at high temperatures. Expression of htrA gene depends on the alternative factor sigmaE and on the two-component regulatory system Cpx. These regulators systems respond, among others factors, to overproduction of misfolded proteins in the periplasm or to high level synthesis of various extracytoplasmic proteins. We describe in this report the osmoregulation of the expression of htrA gene. Low osmolarity conditions result in htrA repression. We report, as well, the role of the nucleoid associated proteins H-NS and Hha in the repression of htrA expression at low osmolarity. |
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Keywords: | HtrA Hha H-NS Osmoregulation Escherichia coli |
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