The drug resistance of Hydrogenobacter thermophilus strain TK-6 |
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Authors: | Yasuo Igarashi Yoshihiro Sanbongi Masaharu Ishii Tohru Kodama |
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Affiliation: | Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan |
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Abstract: | Abstract Hydrogenobacter thermophilus is an extremely thermophilic and obligately autotrophic hydrogen-oxidising bacterium with various unusual properties and believed to occupy a unique taxonomic position. Inhibitory patterns of various antibiotics on the cell growth of H. thermophilus strain TK-6 clearly showed that the bacterium possessed prokaryote-type systems of DNA, RNA and protein syntheses. Effect of ionophore antibiotics supported that the bacterium was a Gram-negative bacterium, but high sensitivities against macrolide and some other antibiotics and insensitivity against polymyxin B were unusual as a Gram-negative eubacterium. Growth inhibition by cell wall synthesis inhibitors revealed the existence of peptidoglycan on the surface of H. thermophilus , but ineffectiveness of cell wall lytic enzymes (lysozyme and lysostaphin) on intact cells and purified cell wall strongly suggested the uniqueness of the cell wall structure of the bacterium. |
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Keywords: | Hydrogenobacter thermophilus Drug resistance |
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