A novel human multi-locus DNA family detected by pJU78 (DF31) |
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| Authors: | Frank Peinemann David N Cooper K -H Grzeschik Jörg Schmidtke |
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| Institution: | (1) Institut für Humangenetik der Universität, Gosslerstrasse12d, W-3400 Göttingen, Germany;(2) Thrombosis Research Institute, Molecular Genetics Section, Manresa Road, SW3 6LR Chelsea, London, UK;(3) Institut für Humangenetik der Universität, Bahnhofstrasse 7a, W-3550 Marburg, Germany;(4) Present address: Abteilung Humangenetik, Medizinische Hochschule, Postfach 610180 W 3000, 61 Hannover, Germany |
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| Abstract: | Summary PJU78 is a 2.9-kb cloned human DNA segment derived from Xq24-q26. When used as a hybridization probe, it detects some 25 related sequences dispersed over the genome, including several autosomes and the X and Y chromosomes. Several pJU78-related sequences were chromosomally allocated and five different restriction fragment length polymorphisms detected and partially characterized in population and family studies. This sequence family was not found in non-primate species. The sequence appears to lack CpG-island character and is not detectably expressed in a variety of human tissues. |
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