6-Dimethylaminopurine (6-DMAP), which is used to produce most cloned animals, is mutagenic in Salmonella typhimurium TA1535 |
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| Authors: | Motoe Katoh Akihiro Araki Takahiro Ogura Ruby P A Valdivia |
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| Institution: | a Genotoxic Risk Assessment Center (CERIG), Universidad de Chile, Olivos 943, Independencia, Santiago, Chile;b Millennium Nucleus in Developmental Biology (MNDB), Santiago, Chile;c Japan Bioassay Research Center (JBRC), Hirasawa, Hadano, Kanagawa 257-0015, Japan |
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| Abstract: | 6-Dimethylaminopurine (6-DMAP) and cycloheximide have recently been used for successful production of cloned mammals. We investigated whether 6-DMAP or cycloheximide are mutagenic agents in the Ames test. Whereas cycloheximide showed no differences compared to the negative control in any of the tester strains, 6-DMAP was clearly mutagenic in Salmonella typhimurium strain TA1535. Here, we strongly propose that innocuous chemicals be used in the production of cloned animals. |
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| Keywords: | 6-Dimethylaminopurine Cycloheximide Ames test Cloned animals |
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