The local edemogenic effects of leukotriene C4 and prostaglandin E2 in rats |
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| Affiliation: | 1. Unit of pharmacology and Biochemistry, Zyma SA, CH-1260 Nyon, Switzerland;1. Molecular Genetics and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University (GIU), 11835, New Administrative Capital, Egypt;2. School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA;3. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt;4. Biotechnology School, Nile University, Giza 12677, Egypt;5. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), Cairo 11835, Egypt;1. IITB- Monash Research Academy, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India;2. Bio- Processing Laboratory, Centre for Technology Alternatives for Rural Areas, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India;3. School of Chemistry, Green Chemical Futures, Monash University, Wellington Road, Clayton, Victoria 3800, Australia;1. School of Arts, Humanities and Social Sciences, Federation University Australia (Gippsland), PO Box 3191, Gippsland, VIC, 3841, Australia;2. School of Social Science, The University of Queensland, Lvl 4, Michie Building, St Lucia, QLD, 4067, Australia;1. Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91198 Gif-sur-Yvette, France;2. Institut Jacques Monod, Université de Paris, CNRS, 75013 Paris, France |
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| Abstract: | Leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) have been studied for their effects on vascular permeability in rats. LTC4 and/or PGE2 were dissolved in 0.3% ethanol and were administered subcutaneously (0.1 ml) in the plantar surface of one of the hind paws of different series of rats. The changes in vascular permeability were measured by the radioactive marker (HSA. I125) method. LTC4 administered in dose of 2 × 10−8M produced marked increase (77 and 133%) in the vascular permeability (local edemogenic effect). PGE2 administered in a dose of 10−6M also produced significant increase (38 and 40%) in the vascular permeability. However, PGE2 in the same dose either administered along with LTC4 or administered at 30 minutes after the injection of LTC4 (2 × 10−8M) did not have any potentiating effect on the edemogenic response of LTC4. |
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