Transport of l-ascorbic acid and dehydro-l-ascorbic acid across renal cortical basolateral membrane vesicles |
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Authors: | John Bianchi Richard C. Rose |
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Abstract: | The uptake of l-ascorbic acid and dehydro-l-ascorbic acid into renal cortical basolateral membrane vesicles has been characterized. The uptake systems for both solutes demonstrate saturation kinetics. The presence of structural analogs of l-ascorbic acid and dehydro-l-ascorbic acid results in cis-inhibition and trans-stimulation. Uptake of each substrate is Na+-independent, proceeding to an endpoint of substrate equilibrium across the vesicular membrane. The transport mechanism(s) for l-ascorbic acid and dehydro-l-ascorbic acid appears to be facilitated diffusion. |
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Keywords: | Ascorbic acid transport Dehydroascorbic acid Basolateral membrane Kinetics (Rat kidney) |
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