Decreased memory T-cell response and function in human
immunodeficiency virus-infected patients with tegumentary
leishmaniasis |
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Authors: | Luana Leandro Gois Sanjay Mehta Maria Zilma Andrade Rodrigues Robert T Schooley Roberto Badaró Maria Fernanda Rios Grassi |
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Institution: | 1. Centro de Pesquisa Gonçalo Moniz-Fiocruz, Salvador, BA, Brasil;2. University of California San Diego, La Jolla, CA, USA ;3. Universidade Federal da Bahia, Salvador, BA, Brasil |
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Abstract: | The effects of human immunodeficiency virus (HIV) on the immune response in patients
with cutaneous leishmaniasis have not yet been fully delineated. This study
quantified and evaluated the function of memory T-cell subsets in response to soluble
Leishmania antigens (SLA) from patients coinfected with HIV and
Leishmania with tegumentary leishmaniasis (TL). Eight TL/HIV
coinfected subjects and 10 HIV seronegative subjects with TL were evaluated. The
proliferative response of CD4+and CD8+T-cells and naïve, central memory (CM) and
effector memory (EM) CD4+T-cells in response to SLA were quantified using flow
cytometry. The median cell division indices for CD4+and CD8+T-cells of coinfected
patients in response to SLA were significantly lower than those in patients with
Leishmania monoinfection (p < 0.05). The proportions of CM and
EM CD4+T-cells in response to SLA were similar between the coinfected patients and
patients with Leishmania monoinfection. However, the median CM and
EM CD4+T-cell counts from coinfected patients were significantly lower (p < 0.05).
The reduction in the lymphoproliferative response to Leishmania
antigens coincides with the decrease in the absolute numbers of both EM and CM
CD4+T-cells in response to Leishmania antigens in patients
coinfected with HIV/Leishmania. |
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Keywords: | Leishmania HIV coinfection memory CD4+ T-cells |
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