Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis

Authors:	Ran Luo Xiongwei Wang Yuanxun Dong Lei Wang Chunlei Tian

Institution:	1.Department of Neurosurgery, Institute of Neurosurgery, Yichang Central People’s Hospital & The First Clinical Medical College of Three Gorges University, Yichang, Hubei 443003, P.R. China

Abstract:	Background The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells. Results The results showed that U87 cells and human glioma tissue expressed PAR2. Exposure to tryptase, or the PAR2 active peptide, increased STAT3 phosphorylation in the radiated U87 cells, reduced U87 cell apoptosis, suppressed the expression of p53 in U87 cells. Conclusions Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. The results implicate that PAR2 may be a novel therapeutic target in the treatment of glioma.

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