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Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines
Affiliation:1. Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China;2. Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230022, China;3. Department of Anesthesiology, the First Affiliated Hospital of Wannan Medical College, Wuhu 241002, China;4. Stroke Center & Department of Neurology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China;5. State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, and Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China;6. Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
Abstract:
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  • Keywords:early-life inflammation  microglial engulfment  ACC  dendritic spines  depressive symptoms  neuronal activity  calcium imaging  chemogenetics
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