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The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity |
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| Authors: | J A Wali D Rondas M D McKenzie Y Zhao L Elkerbout S Fynch E N Gurzov S Akira C Mathieu T W H Kay L Overbergh A Strasser H E Thomas |
| Institution: | 1.St. Vincent''s Institute of Medical Research, Fitzroy, VIC, Australia;2.Department of Medicine, St. Vincent''s Hospital, The University of Melbourne, Fitzroy, VIC, Australia;3.Laboratory for Clinical and Experimental Endocrinology, Leuven, Belgium;4.The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;5.Department of Host Defense, Osaka University, Osaka, Japan;6.Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia |
| Abstract: | |
| Keywords: | type 2 diabetes apoptosis ER stress oxidative stress Bim Puma |