Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism |
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| Authors: | Dyatkin Alexey B Freedman Teresa B Cao Xiaolin Dukor Rina K Maryanoff Bruce E Maryanoff Cynthia A Matthews Jay M Shah Rekha D Nafie Laurence A |
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| Institution: | The R.W. Johnson Pharmaceutical Research Institute, Drug Discovery, Spring House, Pennsylvania 19477-0766, USA. |
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| Abstract: | We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)-1 in CDCl(3) solution was also established. |
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