Changes in topoisomerase I activity after irradiation of lymphoid cells |
| |
| Authors: | Alan Johnstone Ruth McNerney |
| |
| Affiliation: | 1. Department of Immunology, St. George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
|
| |
| Abstract: | The activity of topoisomerase I in nuclear extracts increased about three-fold 5 min after gamma-irradiation (840-2500 rads) of human peripheral blood lymphocytes or cultured lymphoblastoid cells. The change may reflect modification of the enzyme by nuclear ADP-ribosyl transferase, which is known to be activated by DNA breaks. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
