Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors |
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Authors: | Yuning Lei Kye-Il Joo Pin Wang |
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Affiliation: | (1) Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA |
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Abstract: | Background Lentiviral vectors with broad tropism are one of the most promising gene delivery systems capable of efficiently delivering genes of interest into both dividing and non-dividing cells while maintaining long-term transgene expression. However, there are needs for developing lentiviral vectors with the capability to deliver genes to specific cell types, thus reducing the "off-target" effect of gene therapy. In the present study, we investigated the possibility of engineering the fusion-active domain of a fusogenic molecule (FM) with the aim to improve targeted transduction of lentiviral vectors co-displaying an anti-CD20 antibody (αCD20) and a FM. |
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