Secondary Infections,Expanded Tissue Tropism,and Evidence for Malignant Potential in Immunocompromised Mice Infected with Mus musculus Papillomavirus 1 DNA and Virus |
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| Authors: | Nancy M. Cladel Lynn R. Budgeon Timothy K. Cooper Karla K. Balogh Jiafen Hu Neil D. Christensen |
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| Affiliation: | Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicinea;Department of Pathology, Pennsylvania State University College of Medicineb;Department of Microbiology and Immunology, Pennsylvania State University College of Medicinec;Department of Comparative Medicine, Pennsylvania State University College of Medicine,d Hershey, Pennsylvania, USA |
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| Abstract: | Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia. |
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