CD8+ T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2b Mice |
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| Authors: | Kevin B Walsh John Sidney Megan Welch Daniel M Fremgen Alessandro Sette Michael B A Oldstone |
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| Institution: | Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USAa;Center for Infectious Disease, La Jolla Institute for Allergy and Immunology, La Jolla, California, USAb |
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| Abstract: | The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8+ T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8+ T-cell epitopes restricted by H-2Db and/or H-2Kb were identified. These data open the door for using widely profiled, genetically manipulated C57BL/6 mice to study the contribution of epitope-specific CD8+ T cells to PVM pathogenesis. |
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