Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-Analysis |
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| Authors: | Yanwen Yao Xiaoling Gu Juehua Zhu Dongmei Yuan Yong Song |
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| Institution: | 1. Jinling Hospital, Department of Respiratory Medicine, Nanjing University, School of Medicine, Nanjing, China.; 2. Jinling Hospital, Department of Neurology Medicine, Nanjing University, School of Medicine, Nanjing, China.; National Taiwan University, Taiwan, |
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| Abstract: | The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI<25 kg/m2 (OR = 0.65, P = 0.000), and never smokers patients (OR = 0.86, P = 0.042). However, HRT use in patients with artificial menopause could increase the lung cancer risk, OR = 1.51(P = 0.001). The result of Egger''s test did not show any evidence of publican bias (P = 0.069). In conclusion, our meta-analysis on HRT and lung cancer risk suggests that HRT use is correlated with decreased lung cancer risk in female, especially in female with BMI<25 kg/m2 and never smokers. |
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