A Catalyzing Phantom for Reproducible Dynamic Conversion of Hyperpolarized [1-13C]-Pyruvate |
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| Authors: | Christopher M. Walker Jaehyuk Lee Marc S. Ramirez Dawid Schellingerhout Steven Millward James A. Bankson |
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| Affiliation: | 1. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.; 2. Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.; 3. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.; University of California, Irvine, United States of America, |
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| Abstract: | In vivo real time spectroscopic imaging of hyperpolarized 13C labeled metabolites shows substantial promise for the assessment of physiological processes that were previously inaccessible. However, reliable and reproducible methods of measurement are necessary to maximize the effectiveness of imaging biomarkers that may one day guide personalized care for diseases such as cancer. Animal models of human disease serve as poor reference standards due to the complexity, heterogeneity, and transient nature of advancing disease. In this study, we describe the reproducible conversion of hyperpolarized [1-13C]-pyruvate to [1-13C]-lactate using a novel synthetic enzyme phantom system. The rate of reaction can be controlled and tuned to mimic normal or pathologic conditions of varying degree. Variations observed in the use of this phantom compare favorably against within-group variations observed in recent animal studies. This novel phantom system provides crucial capabilities as a reference standard for the optimization, comparison, and certification of quantitative imaging strategies for hyperpolarized tracers. |
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