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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
Affiliation:1. Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg;2. Immunology and Genetics, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7, Avenue des Hauts Fourneaux, Esch-sur-Alzette, Luxembourg;3. Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg;4. Faculty of Science, Technology, and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg;5. Luxembourg Center of Neuropathology, 3555 Dudelange, Luxembourg;6. Epigenetics Team, Systems Biology Group, Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg;7. Department of Bioinformatics and Biochemistry, Braunschweig Integrated Center of Systems Biology, Technische Universität Braunschweig, Rebenring 56, 38106 Braunschweig, Germany;8. Metabolomics Platform, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg;9. National Center of Pathology, Laboratoire National de Santé (LNS), Dudelange, Luxembourg;10. Luxembourg Center for Systems Biomedicine, University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg;11. Department of Life Sciences and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg;12. Department of Cancer Research, Luxembourg Institute of Health, 1526 Luxembourg, Luxembourg;13. Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark
Abstract:
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  • Keywords:pyruvate dehydrogenase  glucose metabolism  citrate  acetyl-CoA  T cells  Th17 cells  experimental autoimmune encephalomyelitis  histone acetylation  epigenetics  IL-17  CP: Immunology  CP: Metabolism
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