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Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress
Affiliation:1. Department of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA;2. Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA;3. Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19103, USA;4. Department of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada;5. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA;6. Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA
Abstract:
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  • Keywords:magnesium channel  calcium channel  MCU  Mrs2  energy imbalance  whole-body metabolism  mitochondrial dysfunction  liver  metabolic syndrome  NAFLD  obesity  HCC  adipose tissue  cardiometabolic disease  hepatocytes  adipose expansion  Western diet  diabetes  metabolic disease  HIF1  CP: Metabolism
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