HMGA2 expression in white adipose tissue linking cellular senescence with diabetes |
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| Authors: | Dominique Nadine Markowski Helge Wilhelm Thies Andrea Gottlieb Heiner Wenk Manfred Wischnewsky J?rn Bullerdiek |
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| Institution: | .Center of Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany ;.Department of General and Vascular Surgery, Clinical Center Bremen-Nord, Hammersbecker Str. 228, 28277 Bremen, Germany ;.Department of Mathematics and Computer Science, University of Bremen, Universitätsallee, 28359 Bremen, Germany |
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| Abstract: | There is a clear link between overweight, gain of white adipose tissue, and diabetes type 2 (T2D). The molecular mechanism of the gain of adipose tissue is linked with the expression of high mobility group protein AT-hook 2 (HMGA2), and recent studies revealed an association with a SNP near HMGA2. In this study, we investigated the gene expression of HMGA2, p14Arf, CDKN1A, and BAX in human abdominal subcutaneous white adipose tissue from 157 patients. We found a significant higher HMGA2 expression in obese individuals than in non-obese patients. Furthermore, the HMGA2 expression in white adipose tissue in patient with type 2 diabetes was significantly higher than in nondiabetic patients. There is an association between the DNA-binding nonhistone protein HMGA2 and the risk of developing T2D that remains mechanistically unexplained so far. Likewise, p14Arf, an inducer of cellular senescence, has been associated with the occurrence of T2D. The data of the present study provide evidence that both proteins act within the same network to drive proliferation of adipose tissue stem and precursor cells, senescence, and increased risk of T2D, respectively.Electronic supplementary materialThe online version of this article (doi:10.1007/s12263-013-0354-6) contains supplementary material, which is available to authorized users. |
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| Keywords: | HMGA2 Subcutaneous abdominal white adipose tissue Type 2 diabetes ADSCs p14Arf |
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