Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation |
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| Authors: | Mizrachy-Schwartz Sarit Cohen Noam Klein Shoshana Kravchenko-Balasha Nataly Levitzki Alexander |
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| Institution: | Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. |
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| Abstract: | We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells. |
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| Keywords: | AMP Kinase Phospholipase C Protein Kinase C (PKC) Signal Transduction Src Cancer |
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