Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy |
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| Authors: | Grigorieff Nikolaus Harrison Stephen C |
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| Institution: | 1 Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02154, United States;2 Harvard Medical School and Children's Hospital, Boston, MA 02115, United States;3 Howard Hughes Medical Institute, United States |
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| Abstract: | Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4? resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry. |
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